Research and Development – Philippine Institute of Pure and Applied Chemistry

A vital part of PIPAC’s package of services is basic and applied research conducted independently or in cooperation with client companies.

Institute Personnel and their Research Interests

- - Armando Victor M. Guidote, Jr., Ph.D.
    Research Interests:
    Organic Chemistry, Natural Products, Chemistry Education
    Click here to see the list of his publications.
  - Armando Jerome H. de Jesus, Jr., Ph.D.
    Research Interests:
    Molecular dynamics simulations, Membrane-protein interactions, Membrane protein-small molecule interactions
    Click here to see the list of his publications.
  - Ronaldo M. Fabicon, Ph.D.
    Research Interests:
    Industrial Chemistry
    Click here to see the list of his publications.
  - Crisanto M. Lopez, Dr.rer.nat
    Research Interests:
    Infection Biology, Fungal Biotechnology
    Click here to see the list of his publications.
  - Giselle Grace F. Lim-Co Yu Kang, Ph.D
    Research Interests:
    Biochemistry, Enzymes, Analytical Chemistry
    Click here to see the list of her publications.
  - Gilbert U. Yu, D.Eng
    Research Interests:
    Materials Science (Polymers and Supramolecules), Chemical Education, Development of Lab Experiment Modules
    Click here to see the list of his publications.
  - Ian Ken D. Dimzon, Ph.D
    Research Interests:
    Applied Analytical Chemistry, Mass Spectrometry, Chemical Metrology
    Click here to see the list of his publications.
  - Anna Carissa M. San Esteban, Ph.D
    Research Interests:
    Electrochemistry (corrosion, electrocatalytic processes); Coordination Chemistry (coordination polymers, metal-organic frameworks)
    Click here to see the list of her publications.

Selected Publications

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2014

Armando M. Guidote Jr.; Ronald L. Reyes; Riyo Kashihara; Yasuhiko Kurusu; Yoshiro Masuyama

Electronic Effects in Oxidation Reactions Utilizing Dinuclear Copper Complexes with the Bis[3-(2-hydroxybenzylideneamino)phenyl] Sulfone Ligand Journal Article

In: KIMIKA, vol. 25, no. 2, pp. 11-22, 2014, ISSN: 2508-0911.

Abstract | Links | Tags: catalysis, copper complex, dinuclear, hydrogen peroxide, oxidation

@article{Guidote2014Electronic,

title = {Electronic Effects in Oxidation Reactions Utilizing Dinuclear Copper Complexes with the Bis[3-(2-hydroxybenzylideneamino)phenyl] Sulfone Ligand},

author = {Armando M. Guidote Jr. and Ronald L. Reyes and Riyo Kashihara and Yasuhiko Kurusu and Yoshiro Masuyama},

url = {https://kimika.pfcs.org.ph/index.php/kimika/article/view/180},

doi = {10.26534/kimika.v25i2.11-22},

issn = {2508-0911},

year  = {2014},

date = {2014-10-20},

journal = {KIMIKA},

volume = {25},

number = {2},

pages = {11-22},

abstract = {Copper acetate and the ligands bis[3-(3-tert-butyl-2-hydroxy-5-methoxybenzylidene-amino)phenyl] sulfone and bis[3-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)phenyl] sulfone were reacted to form the complexes with 2:1 copper:ligand ratio, Cu2[B(t-Bu) (OMe)BAPS](µ-OCH3)2 (4) and with 2:2 copper:ligand ratio, Cu2[B(t-Bu)2BAPS]2 (5),  respectively.  Structures of 4 and 5 were determined based on IR, UV-Vis, and FAB-MS data in comparison with previously characterized related copper complexes. The two complexes 4 and 5 were utilized in the oxidation of the substrates 2,4- and 2,6-di-tert-butylphenol (dtbp) at -50C with H2O2 in CH2Cl2.  The coupling products are preferred in both cases. For 2,4-dtbp, yields of 4,600% and 7,200% of 3,3’,5,5’-tetra-tert-butyl-2,2’-biphenol were achieved with the use of 4 and 5, respectively. For 2,6-dtbp, yields of 1,900% and 400% of 3,3’,5,5’-tetra-tert-butyl-4,4’-biphenol were realized utilizing 4 and 5, respectively. These show that the methoxy groups activated the complex. Based on low temperature UV-vis results, a µ-η2:η2-peroxo or a µ-hydroperoxo intermediate was possibly formed by the reaction of 4 with the H2O2. This effected the oxidation of the 2,4- and 2,6-dtbp substrates but also resulted in the attack of other complexes which acted as substrates.  A proposed oxidation mechanism using complex 4 and related complexes is presented.},

keywords = {catalysis, copper complex, dinuclear, hydrogen peroxide, oxidation},

pubstate = {published},

tppubtype = {article}

}