Research and Development – Philippine Institute of Pure and Applied Chemistry

A vital part of PIPAC’s package of services is basic and applied research conducted independently or in cooperation with client companies.

Institute Personnel and their Research Interests

- - Armando Victor M. Guidote, Jr., Ph.D.
    Research Interests:
    Organic Chemistry, Natural Products, Chemistry Education
    Click here to see the list of his publications.
  - Armando Jerome H. de Jesus, Jr., Ph.D.
    Research Interests:
    Molecular dynamics simulations, Membrane-protein interactions, Membrane protein-small molecule interactions
    Click here to see the list of his publications.
  - Ronaldo M. Fabicon, Ph.D.
    Research Interests:
    Industrial Chemistry
    Click here to see the list of his publications.
  - Crisanto M. Lopez, Dr.rer.nat
    Research Interests:
    Infection Biology, Fungal Biotechnology
    Click here to see the list of his publications.
  - Giselle Grace F. Lim-Co Yu Kang, Ph.D
    Research Interests:
    Biochemistry, Enzymes, Analytical Chemistry
    Click here to see the list of her publications.
  - Gilbert U. Yu, D.Eng
    Research Interests:
    Materials Science (Polymers and Supramolecules), Chemical Education, Development of Lab Experiment Modules
    Click here to see the list of his publications.
  - Ian Ken D. Dimzon, Ph.D
    Research Interests:
    Applied Analytical Chemistry, Mass Spectrometry, Chemical Metrology
    Click here to see the list of his publications.
  - Anna Carissa M. San Esteban, Ph.D
    Research Interests:
    Electrochemistry (corrosion, electrocatalytic processes); Coordination Chemistry (coordination polymers, metal-organic frameworks)
    Click here to see the list of her publications.

Selected Publications

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2011

Agnes T. Aranas; Armando M. Guidote Jr.; Paul R. Haddad; Joselito P. Quirino

Sweeping–micellar electrokinetic chromatography for the simultaneous analysis of tricyclic antidepressant and β-blocker drugs in wastewater Journal Article

In: Talanta, vol. 85, no. 1, pp. 86-90, 2011, ISSN: 0039-9140.

Abstract | Links | Tags: micellar electrokinetic chromatography, on-line sample preconcentration, sweeping, tricyclic antidepressant drugs, β-blocker drugs

@article{Aranas2011,

title = {Sweeping–micellar electrokinetic chromatography for the simultaneous analysis of tricyclic antidepressant and β-blocker drugs in wastewater},

author = {Agnes T. Aranas and Armando M. Guidote Jr. and Paul R. Haddad and Joselito P. Quirino},

url = {https://www.sciencedirect.com/science/article/abs/pii/S0039914011002372},

doi = {10.1016/j.talanta.2011.03.032},

issn = {0039-9140},

year  = {2011},

date = {2011-03-15},

journal = {Talanta},

volume = {85},

number = {1},

pages = {86-90},

abstract = {The simultaneous analysis of tricyclic antidepressant (amitriptyline, clomipramine, doxepin and nortriptyline) and β-blocker (alprenolol, labetalol and propranolol) drugs in wastewater was developed via sweeping–micellar electrokinetic chromatography (MEKC) together with a simple liquid–liquid extraction step. For sweeping–MEKC, the amount of organic modifier in the separation electrolyte, the concentration of phosphoric acid in the sample matrix and the injection time of the sample were optimized. Sensitivity enhancements of up to 305-fold were achieved via sweeping. This allowed limits of detection (LOD) from 7 to 27 ng/mL. The relative standard deviations of migration time, corrected peak area and peak height were less than 3.2%, 7.8% and 4.5%, respectively. Liquid–liquid extraction using dichloromethane as solvent afforded up to 21-fold enrichment of the drugs from spiked wastewater. No interference of the sample matrix was observed and recoveries were obtained in the range of 77–113% for all analytes except labetalol at three spiking levels of 16, 80 and 160 ng/mL. Detection at the ng/mL level makes this simple, environmentally friendly and cost effective method competitive against recently reported methods using advanced liquid-phase separation techniques for monitoring similar drugs in wastewater.},

keywords = {micellar electrokinetic chromatography, on-line sample preconcentration, sweeping, tricyclic antidepressant drugs, β-blocker drugs},

pubstate = {published},

tppubtype = {article}

}